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NNMT depletes the NAD+ precursor pool by methylating nicotinamide the same nicotinamide that the salvage pathway would otherwise convert back into NAD+ via the enzyme NAMPT

B12 can show results for fatigue caused by deficiencies since it replenishes what the body is missing

This is where the question of how much b12 injections are becomes a necessary part of a long-term health plan

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